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Study updates

Impact of maternal vaccination on immunity to whooping cough

"Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy- a prospective, observational cohort study from the UK"

Published in Clinical and Experimental Immunology, 2019

LAY SUMMARY

In this study, we recruited mothers who were unvaccinated, or who received vaccination against whooping cough (pertussis) during pregnancy. We collected blood samples from these mothers and from their infants to measure their levels of antibody.

Our main findings were:

1) Mothers who were unvaccinated had low levels of antibody against the whooping cough bacteria- usually below levels that would protect against disease. These women are therefore vulnerable to catch whooping cough

2) Mothers who were vaccinated had a good immune response to the vaccine, and had much higher levels of antibody against the whooping cough bacteria- protecting them from disease.

3) All mothers transferred antibody to their babies

4) If women were vaccinated in pregnancy, their babies had significantly higher levels of protective antibody at birth and at 7 weeks- when babies are most vulnerable whooping cough, and are most likely to be hospitalised as a result.

5) Babies also had higher levels of antibodies against other diseases covered by the vaccine- such as diphtheria and tetanus

6) After babies had their own vaccines against whooping cough, there was no difference in the amount of antibody they had depending on whether their mother was vaccinated in pregnancy, or not.

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Impact of maternal vaccination on immunity to flu

"The impact of timing of maternal influenza immunization on infant antibody levels at birth" 

Published in Clinical and Experimental Immunology, 2019

Lay description

Children in Playground

Awareness and uptake of maternal vaccination in 2013-2014

"What determines uptake of pertussis vaccination in pregnancy? A cross sectional survey in an ethnically diverse population of pregnant women in London"

Published in Vaccine, 2015

Lay description

Moms and Babies
 

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